Fungicidal against dermatophytes, moulds and certain dimorphic fungi.
Treatment choice in therapy of onychomycosis because of effectiveness
More efficacious than griseofulvin in treating tinea capitis caused by Trichophyton species
Terbinafine is used in the treatment of dermatophytoses, especially onychomycosis.
Approximately 75% of oral terbinafine is absorbed, but only 5% or less from unbroken skin. First pass metabolism further reduces oral bioavailability.
It is inactivated by metabolism and excreted in urine(80%) and faeces (20%); elimination t1/2 of 11-16 hr is prolonged to 10 days after repeated dosing.
It is lipophilic, widely distributed in the body, strongly plasma protein bound and concentrated in sebum, stratum corneum and nail plates.
Highly keratophilic with a bioavailability of 70% to 80%
Well tolerated with low potential for drug interactions
